Monday, January 14, 2008

Grow Your Own Heart

Okay, picture this potential scenario for the not-so-distant-future: You've spent your adult life overweight, eating poorly, no real exercise, smoking, heavy drinking, and with a family history of organ-affecting ailments like heart disease (sorta like me, except for the smoking and heavy drinking parts). Then one day – Bang! – your transgressions come slamming home to you when you have a heart attack. You're rushed to the hospital and saved in the nick of time.

From then on you're stuck on massive heart medicine, maybe have a bypass or two, or even require a heart transplant or artificial heart, right? Maybe not.

They may be able to grow you a spankin' new heart!

That's right. While you are kept alive with more traditional methods, the hospital can simply order you a new heart. They would take a cadaver's heart (or maybe even a pig heart) and "decellularize" it. In other words, they would pump detergents into the donor heart to kill all of its cells, leaving behind only the extracellular matrix – a sort of natural scaffold. Then they would infuse that scaffold with your own stem cells that had been differentiated into heart cells and repopulate the scaffold with them. After a few weeks, the heart would be pumping and ready to transplant into your body. Because they are your own cells, rejection is not as likely, and you could go on your happy, gluttonous way.

Some scientists from the University of Minnesota Center for Cardiovascular Repair recently took the first real steps toward this science fiction-esque scenario:

http://www.physorg.com/news119445798.html

Scholarly paper, published online in Nature Medicine on Jan. 13: http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm1684.html

They infused "scaffolds" of rat and pig hearts with live progenitor cells from newborn rats. The cells differentiated into heart cells then organized themselves and proliferated around the scaffold. After only four days the tissue started having contractions. After eight days, the heart was beating. It's alive! ALIVE!! Mwa ha ha ha ha!

And what this tell-tale heart tells us, in its rhythmic way, is that we may be able to do this with other organs. We can already make artificial blood vessels, skin, and bladders. Now we may be able to make not only hearts but also kidneys, livers, and other "complex" organs. Heck, pretty soon the scaffolds will be artificially grown, too!

Why, there could be no end to the partying, folks! Slam down another bottle of Jack Daniels and huff another pack of cigs, we're living the high life! If you wear out your organs, just order up new ones!

And as for me, seeing as how I already have a mild heart problem and have family with heart and circulatory problems (an aunt and a cousin have had bypasses, and my maternal grandfather died after multiple heart attacks), I guess I can take heart that I may have another option pumping for me in the future.


Image taken from HERE.

48 comments:

RBH said...

Having a family history something like yours, having already had an M.I. and with three stents in my coronary arteries, I hope those guys get on the horses! :)

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